Symptoms of bipolar depression

For some patients with bipolar disorder, the depressive symptoms, also called bipolar depression, can be more disabling than the manic symptoms. It's important that you discuss all your symptoms with your health care professional, including any manic episodes. The depressive symptoms of bipolar disorder are similar to, and in fact often misdiagnosed as, symptoms of major depressive disorder. To be diagnosed with bipolar disorder you must have experienced a high period of either mania or hypomania (a less severe form of mania). So be sure to talk to your health care professional about all the symptoms you are experiencing, including any manic episodes. This will help your health care professional recognize the differences between these often-similar disorders. Seroquel XR is not approved to treat major depressive disorder.

Some of the symptoms of bipolar depression include

  • Sadness
  • Feelings of worthlessness
  • Losing interest in things and activities you once enjoyed
  • Being overcome by feelings of guilt, failure, and hopelessness
  • Becoming sad and unable to concentrate, remember things, or even make simple decisions
  • Experiencing physiological changes like differences in appetite or weight, energy levels, and sleep schedules
  • Possibly thinking about death or suicide, in extreme cases

Bipolar depression can be treated effectively—with medications, lifestyle changes, and therapy. Treatment options may help limit the impact bipolar depression has on your life, your family, and your friends. Some treatment options may also help prevent depressive episodes from recurring or becoming more severe.

Learn more about what bipolar depression is.

Is Seroquel XR right for you?

Learn more

The information on this Web site should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about Seroquel XR, talk to your doctor or pharmacist. Only you and your health care professional can decide if Seroquel XR is right for you.

Important Safety Information and Indications for Seroquel XR

Elderly patients with dementia-related psychosis (having lost touch with reality due to confusion and memory loss) treated with this type of medicine are at an increased risk of death, compared to placebo (sugar pill). Seroquel XR is not approved for treating these patients.

Antidepressants have increased the risk of suicidal thoughts and actions in some children, teenagers, and young adults. Patients of all ages starting treatment should be watched closely for worsening of depression, suicidal thoughts or actions, unusual changes in behavior, agitation, and irritability. Families and caregivers should watch patients daily and report these symptoms immediately to the physician. Seroquel XR is not approved for patients under the age of 18 years.

  • High blood sugar and diabetes have been reported with Seroquel XR and medicines like it. If you have diabetes or risk factors such as obesity or a family history of diabetes, ask your doctor about checking your blood sugar before starting Seroquel XR and regularly throughout treatment. If you develop symptoms of high blood sugar or diabetes, such as excessive thirst or hunger, increased urination, or weakness, contact your doctor. Complications from diabetes can be serious and even life threatening
  • Increases in cholesterol and triglycerides, and weight gain have been reported with Seroquel XR
  • A rare, but potentially fatal, side effect reported with Seroquel XR and medicines like it is neuroleptic malignant syndrome (NMS). Tell your doctor if you have very high fever; rigid muscles; shaking; confusion; sweating; changes in pulse, heart rate, or blood pressure; or muscle pain and weakness because treatment should be stopped if you have NMS
  • Another serious side effect reported with Seroquel XR and medicines like it is tardive dyskinesia (TD)—uncontrollable movements of the face, tongue, or other parts of the body. TD may become permanent, and the risk of TD is believed to increase as the length of time on and the amount of these medications increase. While TD can develop in patients taking low doses for short periods, this is much less common. There is no known treatment for TD, but it may go away partially or completely if treatment is stopped
  • Before starting treatment, tell your doctor if you have high prolactin levels or have a history of, or are at risk for, seizures or a low white blood cell (WBC) count. An eye exam for cataracts is recommended at the beginning of treatment and every 6 months thereafter
  • During treatment, tell your doctor if you feel dizzy or lightheaded upon standing, or if you have trouble swallowing
  • Suicidal thoughts or actions may occur; tell your doctor if you have thoughts about death or suicide
  • Since drowsiness has been reported with Seroquel XR, you should not participate in activities such as driving or operating machinery until you know that you can do so safely. Avoid drinking alcohol while taking Seroquel XR because Seroquel XR increases the effects of alcohol. Avoid becoming overheated or dehydrated while taking Seroquel XR
  • Common side effects: The most common side effects are drowsiness, dry mouth, increases in cholesterol and triglycerides, constipation, upset stomach, dizziness, a sudden drop in blood pressure upon standing, weight gain, increased hunger, tiredness, increases in blood sugar, difficulty speaking, and stuffy nose

This is not a complete summary of safety information. Please discuss the full Prescribing Information with your health care provider.

Indications

Seroquel XR is a once-daily tablet approved to treat acute depressive episodes in bipolar disorder; acute manic or mixed episodes in bipolar disorder alone or when added to lithium or divalproex; long-term maintenance of bipolar disorder when added to lithium or divalproex; and schizophrenia.

Click here to see Prescribing Information for Seroquel XR, including Boxed Warnings.

Please see the last page of the Prescribing Information for the Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Patient photos are intended to be representative of typical patients with bipolar disorder and are not of actual patients.

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