Organizations

AstraZeneca has long supported the mental health community and initiatives to assist people with major depressive disorder, bipolar depression, and other conditions in living healthier, more productive lives. AstraZeneca is proud to support programs that can help you and your family in partnership with many leading mental health organizations, such as the National Alliance on Mental Illness, the Depression and Bipolar Support Alliance, The Jed Foundation, Mental Health America, Families for Depression Awareness, and the National Council for Community Behavioral Healthcare.

National Alliance on Mental Illness (NAMI)

3803 N. Fairfax Drive, Suite 100
Arlington, VA 22203
800-950-NAMI (6264)
www.nami.org

NAMI Connection
NAMI Connection support groups are for people who are living with mental illness. These groups hold regular meetings and are intended for people with any mental illness who seek to learn from others' experiences, share coping strategies, and offer encouragement, understanding, and support. Groups are available around the country. To find available groups near you, visit www.nami.org/connection.

Peer-to-Peer
A nine-week educational program on the topic of mental illness for any person with a psychiatric diagnosis. It provides information on the biological bases of mental illness; emotions, advocacy, and empowerment; and coping and treatment strategies. It is taught by mentors who have personally experienced mental illness. Find a course near you at www.nami.org/P2P.

Depression and Bipolar Support Alliance

730 N. Franklin Street, Suite 501
Chicago, IL 60654
800-826-3632
www.dbsalliance.org

Facing Us
An online program designed to highlight the "face" of bipolar disorder and depression, and supply tools to those facing the challenges of living with these illnesses. Individuals can submit their own short video clips about facing depression, facing bipolar disorder, facing relationships, and facing recovery. FacingUs.org hosts an online support group community where individuals can find tools necessary to manage their illness, including a downloadable "Wellness Tracker." Visit www.facingus.org for more information.

The Jed Foundation

220 Fifth Avenue, 9th Floor
New York, NY 10001
212-647-7544
www.jedfoundation.org

Half of Us
A social outreach campaign for college students to help bring awareness of mental health issues. Run through the mtvU network, Half of Us uses TV and the Web to link millions of students nationwide to the mental health resources they need. Half of Us is the largest, most comprehensive mental health outreach campaign for college students in the US. Learn more at www.halfofus.com.

MedlinePlus

US National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
www.nlm.nih.gov/medlineplus

MedlinePlus will direct you to information to help answer health questions. MedlinePlus brings together authoritative information from the National Library of Medicine, the National Institutes of Health, and other government agencies and health-related organizations. Preformulated Medline searches are included in MedlinePlus and provide easy access to references to medical journal articles. MedlinePlus also has extensive information about drugs and supplements, an illustrated medical encyclopedia, interactive patient tutorials, the latest health news, and surgery videos.

National Council for Community Behavioral Healthcare

1701 K Street NW, Suite 400
Washington, DC 20006
www.thenationalcouncil.org

The National Council for Community Behavioral Healthcare serves more than six million adults and children with mental illnesses and addiction disorders. The NCCBH is committed to providing comprehensive, quality care that affords every opportunity for recovery and inclusion in all aspects of community life.

The NCCBH also offers Mental Health First Aid, a certification program similar to CPR that helps health care providers, educators, faith leaders, employers, and others learn to recognize a mental health crisis and also provide resources and direction for treatment options. The program helps to combat stigma, educate key audiences, and improve access to treatment for individuals with mental illnesses. For more information, visit www.thenationalcouncil.org.

Families for Depression Awareness

395 Totten Pond Road, Suite 404
Waltham, MA 02451
781-890-0220
www.familyaware.org

The Mental Health Family Tree
The Mental Health Family Tree program raises awareness of the possible family connection of bipolar disorder. Through the use of a simple Web-based tool, individuals can map out their family's history of mental illness and print out their family tree for their next doctor or other health care professional visit. Build your own family tree at www.mentalhealthfamilytree.org.

Mental Health America

2000 N. Beauregard Street, 6th Floor
Alexandria, VA 22311
800-969-6MHA (6642)
www.nmha.org

Mental Health America is the nation's largest and oldest community-based network dedicated to helping all Americans live mentally healthier lives. With more than 300 affiliates across the country, they touch the lives of millions—advocating for changes in policy, educating the public and providing critical information, and delivering urgently needed programs and services.

National Hopeline Network

800-784-2433
www.hopeline.com

A national network connecting our country's crisis centers under a single, easy-to-remember toll-free telephone number: 1-800-SUICIDE.

Organizations for Health Care Professionals

American Psychiatric Association (APA)

1000 Wilson Blvd, Suite 1825
Arlington, VA 22209
888-35-PSYCH (77924)
www.psych.org

The APA is an organization of psychiatrists working together to ensure humane care and effective treatment for all persons with mental disorders, including mental retardation and substance-related disorders.

National Institute of Mental Health (NIMH)

Public Information and Communications Branch
6001 Executive Blvd, Room 8184, MSC 9663
Bethesda, MD 20892
866-615-6464
www.nimh.nih.gov

The mission of the NIMH is to transform the understanding and treatment of mental illness through basic and clinical research, paving the way for prevention, recovery, and cure.

Important Safety Information and Indications for Seroquel XR and Seroquel

Elderly patients with dementia-related psychosis (having lost touch with reality due to confusion and memory loss) treated with this type of medicine are at an increased risk of death, compared to placebo (sugar pill). Seroquel XR and Seroquel are not approved for treating these patients.

Antidepressants have increased the risk of suicidal thoughts and actions in some children, teenagers, and young adults. Patients of all ages starting treatment should be watched closely for worsening of depression, suicidal thoughts or actions, unusual changes in behavior, agitation, and irritability. Patients, families, and caregivers should pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed. Report any change in these symptoms immediately to the doctor. Seroquel XR is not approved for patients under the age of 18 years. Seroquel is not approved for patients under the age of 10 years.

Stop Seroquel XR or Seroquel and call your doctor right away if you have some or all of the following symptoms: high fever; stiff muscles; confusion; sweating; changes in pulse, heart rate, and blood pressure. These may be symptoms of neuroleptic malignant syndrome (NMS), a rare and serious condition that can lead to death
High blood sugar and diabetes have been reported with Seroquel XR, Seroquel, and medicines like them. If you have diabetes or risk factors such as obesity or a family history of diabetes, your doctor should check your blood sugar before you start taking Seroquel XR or Seroquel and also during therapy. If you develop symptoms of high blood sugar or diabetes, such as excessive thirst or hunger, increased urination, or weakness, contact your doctor. Complications from diabetes can be serious and even life threatening
Increases in triglycerides and in LDL (bad) cholesterol and decreases in HDL (good) cholesterol have been reported with Seroquel XR and Seroquel. Your doctor should check your cholesterol levels before you start Seroquel XR or Seroquel and during therapy
Weight gain has been reported with Seroquel XR and Seroquel. Your doctor should check your weight regularly
Tell your doctor about any movements you cannot control in your face, tongue, or other body parts, as they may be signs of a serious condition called tardive dyskinesia (TD). TD may not go away, even if you stop taking Seroquel XR or Seroquel. TD may also start after you stop taking Seroquel XR or Seroquel
Other risks include feeling dizzy or lightheaded upon standing, decreases in white blood cells (which can be fatal), or trouble swallowing. Tell your doctor if you experience any of these
Increases in blood pressure have been reported with Seroquel in children and teenagers. Your doctor should check blood pressure in children and adolescents before starting Seroquel and during therapy
Before starting treatment, tell your doctor about all prescription and nonprescription medicines you are taking. Also tell your doctor if you have or have had low white blood cell count, seizures, abnormal thyroid tests, high prolactin levels, heart or liver problems, or cataracts. An eye exam for cataracts is recommended at the beginning of treatment and every 6 months thereafter
Since drowsiness has been reported with Seroquel XR and Seroquel, you should not participate in activities such as driving or operating machinery until you know that you can do so safely. Avoid becoming overheated or dehydrated while taking Seroquel XR or Seroquel. Do not drink alcohol while taking Seroquel XR or Seroquel
Tell your doctor if you are pregnant or intend to become pregnant. Avoid breast-feeding while taking Seroquel XR or Seroquel
For Seroquel XR, the most common side effects in adults are drowsiness, dry mouth, constipation, dizziness, increased appetite, upset stomach, weight gain, fatigue, disturbance in speech and language, and stuffy nose. For Seroquel, the most common side effects in adults are drowsiness, dry mouth, dizziness, constipation, weakness, abdominal pain, a sudden drop in blood pressure upon standing, sore throat, weight gain, sluggishness, abnormal liver tests, and upset stomach. The most common side effects in children and adolescents are drowsiness, dizziness, fatigue, increased appetite, nausea, vomiting, dry mouth, rapid heartbeat, and weight gain
Do not stop taking Seroquel XR or Seroquel without talking to your doctor. Stopping Seroquel XR or Seroquel suddenly may cause side effects

This is not a complete summary of safety information. Please discuss the full Prescribing Information for both products with your health care provider.

Indications

Seroquel XR is a once-daily tablet approved in adults for (1) add-on treatment to an antidepressant for patients with major depressive disorder (MDD) who did not have an adequate response to antidepressant therapy; (2) acute depressive episodes in bipolar disorder; (3) acute manic or mixed episodes in bipolar disorder alone or with lithium or divalproex; (4) long-term treatment of bipolar disorder with lithium or divalproex; and (5) schizophrenia. Seroquel is approved for (1) acute depressive episodes in bipolar disorder in adults; (2) acute manic episodes in bipolar disorder in adults when used alone or with lithium or divalproex; (3) acute manic episodes in bipolar disorder in children and adolescents ages 10 to 17 years; (4) long-term treatment of bipolar disorder in adults with lithium or divalproex; (5) schizophrenia in adults and (6) schizophrenia in adolescents ages 13-17 years.

Click here to see the Prescribing Information for Seroquel XR, including Boxed Warnings.

Click here to see the Medication Guide for Seroquel XR.

Click here to see the Prescribing Information for Seroquel, including Boxed Warnings.

Click here to see the Medication Guide for Seroquel.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

The information on this Web site should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about Seroquel XR, talk to your doctor or pharmacist. Only you and your health care professional can decide if Seroquel XR is right for you.

Patient photos are intended to be representative of typical patients with bipolar disorder and/or major depressive disorder and are not of actual patients.

Prescribing Information

Medication Guides